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针对自闭症谱系障碍的基于微生物群的干预措施:对疗效和临床潜力的系统审查

Hana Taha^1,2, Ahmad Issa¹, Zaid Muhanna¹

¹Department of Family and Community Medicine, School of Medicine, The University of Jordan, Amman, Jordan.

Frontiers in microbiology

|October 13, 2025

概括

基于微生物群的干预措施对自闭症谱系障碍 (ASD) 是有前途的. 便微生物种移植 (FMT) 在ASD行为和胃肠道症状方面提供了持续的改善,而益生菌,益生菌和协生菌则显示出不同的疗效.

科学领域:

神经科学和胃肠道学
微生物组研究微生物组研究
临床治疗学临床治疗学

背景情况:

自闭症谱系障碍 (ASD) 越来越多地与肠道微生物群失调有关.
这种不平衡会影响ASD患者的行为和胃肠道 (GI) 症状.
了解肠-大脑轴对于开发有效的ASD管理策略至关重要.

研究的目的:

系统地审查基于微生物群的干预措施对ASD症状的有效性.
评估益生菌,益生菌,协生菌和便微生物种移植 (FMT).
为治疗潜力提供见解,并指导未来的临床应用.

主要方法:

在PROSPERO (CRD42024615043) 中注册的,遵循PRISMA指南的系统审查.
在PubMed,Cochrane图书馆和Scopus中搜索相关的同行评审研究 (RCT,NRT,回顾性).
两个独立的审查员评估了研究选择,数据提取和偏差风险.

主要成果:

包括33项研究 (16项RCT,14项NRT,3项追溯).
益生菌显示出适度的行为改善;多菌株配方更有效.
便微生物种移植 (FMT) 在ASD行为和肠道功能方面显示出最一致和持续的改善,副作用最小.

结论:

针对微生物群的干预措施,特别是FMT,对ASD症状管理具有重大前景.
益生菌,益生菌和共生菌具有不同的疗效.
为了优化治疗策略,需要进一步研究标准化方案,更大规模的受控试验和个性化方法.

关键词:

自闭症谱系障碍自闭症谱系障碍便中的微生物群基于微生物群的疗法益生菌益生菌益生菌益生菌益生菌是一种益生菌.综合生物 synbiotics 综合生物移植移植移植移植

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