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维生素D水平与下肢骨折的愈合时间之间的相关性
Romin Memon1, Pratik Raj2, Mohit Sheoran3
1Department of Trauma and Orthopedic, East Suffolk and North Essex Foundation Trust, United Kingdom.
Journal of orthopaedic case reports
|October 13, 2025
概括
较低的维生素D水平与下肢骨折的愈合时间延长有关. 解决维生素D缺乏症可能会改善骨折愈合结果.
科学领域:
- 整形外科 整形外科 整形外科
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
背景情况:
- 维生素D对于酸代谢和骨愈合至关重要.
- 维生素D缺乏在骨折患者中很普遍,可能会延迟结合,特别是在下肢骨折中.
研究的目的:
- 调查基线血清维生素D水平与下肢骨折的愈合时间之间的关联.
主要方法:
- 120名患有急性下肢骨折的成年患者的前性,观察性多中心研究.
- 在受伤一周内评估血清25-氧维生素D水平,分为充足 (>30 ng/mL),不足 (20-30 ng/mL) 或缺乏 (<20 ng/mL).
- 治愈时间由临床和放射学确定;统计分析包括相关性和回归模型.
主要成果:
- 平均维生素D水平为21.6 ± 8.4 ng/mL,缺乏45%.
- 平均愈合时间为16.4±3.8周,与缺乏维生素D (16.7周) 和缺乏维生素D (17.9周) 组相比,获得足够维生素D的患者 (14.8周) 的愈合时间明显更快 (P<0.001).
- 维生素D水平是愈合时间 (β = -0.41,P < 0.001) 的独立预测因素,与愈合时间 (r = -0.62,P < 0.001) 有负相关.
结论:
- 较低的基线维生素D水平与下肢骨折的延迟结合和更长的愈合持续时间相关.
- 常规查和维生素D缺陷的纠正可能会提高受影响患者的骨折愈合结果.
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