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Knarik V Yeritsyan1, Artem V Badasyan1

  • 1Materials Research Laboratory, University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia.

ACS omega
|October 13, 2025
PubMed
概括

FitFoldData是一个新的网络工具,用于使用循环二元化 (CD) 和微分扫描热量计 (DSC) 分析蛋白质热变性. 它提供了对蛋白质稳定性所需的结能量的洞察.

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Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...