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在长期受到压力的小鼠中,PERK介导的细胞内膜网膜过度激活引起的丸损伤

Lixuan Peng^1,2, Xiaohan Tang^1,3, Pingping Tang¹

¹Clinical Anatomy and Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.

|October 13, 2025

概括

慢性压力会通过激活丸内细胞内网膜应激 (ERS) 来导致男性不孕. 用ISRIB抑制ERS可以改善精子质量并恢复生殖功能.

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
细胞应激反应的应激反应

背景情况:

细胞内网膜应激 (ERS) 与精子生成有关.
关于ERS在慢性压力诱导的男性不孕症中的作用的数据有限.

研究的目的:

调查慢性克制压力 (CRS) 对男性不孕症ERS的影响.
确定抑制ERS是否可以减轻CRS诱导的丸损伤.

主要方法:

雄性小鼠接受了慢性克制压力 (CRS).
用ERS抑制剂ISRIB进行了评估,以评估其保护作用.
评估了ERS蛋白质,精子参数,丸组织学,类固醇生成,激素水平和神经激活.

主要成果:

在丸中,CRS激活了PERK介导的ERS通路.
ISRIB治疗改善了丸结构,精子质量和类固醇酶表达.
ISRIB降低了皮质,使下丘脑激活正常化,并增加了GnRH水平.

结论:

在丸中,CRS会提高p-PERK的表达,从而导致不孕.
ISRIB治疗改善了CRS诱导的丸损伤和改善了精子质量.
恢复HPA和HPG轴的功能可能是ISRIB有益影响的基础.

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