患者报告结果的性别差异 艾滋病毒感染者转向口服双重治疗:PROBI研究的结果
Tristan Alain1, Fabienne Marcellin2, Pascal Bessonneau1
1Patient-Reported Outcomes Research (PROQOL), Health Economics Clinical Trial Unit (URC-ECO), Hotel-Dieu Hospital, AP-HP, Paris, France.
AIDS research and treatment
|October 13, 2025
概括
双重治疗改善了艾滋病毒感染者 (PLWH) 的健康相关生活质量 (HRQL). 然而,与男性相比,女性始终报告精神和认知HRQL较低,尽管治疗效益相似.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 公共卫生 公共卫生
- 临床药理学 临床药理学
背景情况:
- 艾滋病毒结果中的性别差异受社会经济,行为和心理社会因素的影响.
- 艾滋病毒感染女性的治疗中止率较高.
- 了解与健康相关的生活质量 (HRQL) 差异对于优化艾滋病毒护理至关重要.
研究的目的:
- 评估艾滋病毒感染者 (PLWH) 转向口服双重治疗的治疗可接受性,感知毒性和HRQL.
- 分析HRQL和治疗结果的基于性别的差异.
- 为了确定影响女性中断治疗的因素.
主要方法:
- 预期观察性研究 (PROBI) 收集了基线,1个月和6个月的HRQL,治疗可接受性和症状负担数据.
- 用适当的统计测试分析性别差异.
- 混合效应线性回归模型用于评估 HRQL 随时间变化的变化.
主要成果:
- 该研究包括260名PLWH (35%的女性),女性具有不同的人口和社会经济特征.
- 虽然所有参与者都表现出更好的HRQL和治疗接受度,但女性始终报告精神和认知HRQL得分较低 (平均差异:7分).
- 尽管没有病毒学失败,但与男性 (5%) 相比,女性的治疗中止率更高 (15%).
结论:
- 口服双重治疗改善了艾滋病毒感染者男性和女性的HRQL和治疗可接受性.
- 妇女持续经历了更糟糕的心理和认知HRQL,突出了针对性干预的需要.
- 建议加强患者与医疗服务提供者之间的沟通,以解决HRQL变化并减轻停药风险,特别是在女性中.
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