美国肥胖成年人尿肠乳酸与睡眠质量之间的关系的横截面研究
Qiaoli Xu1, Yisen Huang1, Xinqi Chen1
1Department of Gastroenterology, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, Fujian, People's Republic of China.
Nature and science of sleep
|October 13, 2025
概括
尿路肠乳水平较高,表明肠道健康更好,与肥胖美国成年人的睡眠质量改善有关. 这表明,在这个人群中,饮食或微生物可能对睡眠产生影响.
科学领域:
- 营养科学 营养科学
- 睡眠医学 睡眠医学
- 微生物组研究 微生物组研究
背景情况:
- 肥胖是一个重要的公共卫生问题,与各种并发症有关,包括睡眠障碍.
- 肠道细菌从食中干素产生的代谢物 - - 肠杆菌,被认为是肠道微生物群活动的生物标志物,也是饮食质量的潜在指标.
- 睡眠质量差在肥胖人口中普遍存在,并对整体健康和福祉产生负面影响.
研究的目的:
- 在一组肥胖的美国成年人中,研究尿路肠乳水平与睡眠质量之间的关联.
- 探索肠乳和睡眠质量指标之间的剂量反应关系.
- 为了确定该协会是否在不同的人口学子组之间有所不同.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) 数据库 (2005-2008) 913名肥胖成年人的数据分析.
- 测量尿路肠乳度和评估睡眠质量,使用经过验证的PSQI类指数.
- 应用多变量逻辑回归和受限立方线用于关联和剂量反应分析,并对子组调查进行分层分析.
主要成果:
- 观察到尿路内肠乳和睡眠质量差之间存在显著的反向关联,每单位增加的日志转化肠乳与睡眠不良的几率降低8%相关 (OR=0.92,p=0.027).
- 显而易见的是剂量与反应的关系,较高的肠乳水平与更好的睡眠质量相关.
- 在分层分析中,观察到的关联在各种子组中保持一致.
结论:
- 尿中的肠乳水平与美国肥胖成年人睡眠质量差异相反.
- 作为肠道微生物组功能的标志物,肠道乳可能在调节这一群体的睡眠质量方面发挥作用.
- 研究结果强调了饮食,肠道健康和睡眠在肥胖管理中的潜在相互作用.
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