在IA期肺腺癌中内脏变化的预后意义:一项回顾性研究
Yingding Ruan1, Yuhe You2, Jianwei Han1
1Department of Thoracic Surgery, The First People's Hospital of Jiande, Jiande, China.
Frontiers in oncology
|October 13, 2025
概括
在早期肺癌患者中,内脏膜变化 (VPC) 并没有影响整体存活率 (OS). 然而,VPC存在与更好的无病生存率 (DFS) 有关,这表明VPC不是IA期肺腺癌的负面预后因素.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
背景情况:
- 在早期的肺腺癌中,越来越多地观察到内脏膜变化 (VPC).
- 在这些患者中,VPC的临床和预后影响尚不清楚.
研究的目的:
- 研究VPC对整体存活率 (OS) 和无病存活率 (DFS) 的影响.
- 在被诊断为IA期肺腺癌的患者中评估VPC的意义.
主要方法:
- 来自两个机构的494名患有IA期肺腺癌的患者的回顾性分析.
- 1:1倾向分数匹配 (PSM) 创建可比的VPC阳性 (VPC+) 和VPC阴性 (VPC-) 组 (每组142名患者).
- 使用Kaplan-Meier和Cox回归分析来评估生存结果并确定预后因素.
主要成果:
- 在VPC+和VPC-组之间没有观察到OS的显著差异 (P=0.320).
- 与VPC-组相比,VPC+组的DFS显著更好 (HR0.51,P=0.028).与VPC-组相比,VPC+组的DFS显著更好.
- 操作时间,VPC状态和病理阶段IA3被确定为DFS的独立预后因素.
结论:
- 与VPC阳性状态相比,在IA期肺腺癌中,VPC阴性状态与更糟糕的DFS有关.
- 在VPC+和VPC-患者之间没有发现OS的显著差异.
- 病理阶段是该患者队列中DFS的显著预后因素.
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