在一个多民族亚洲队列中的新型eGFR方程和心血管结果
Zhong Hong Liew1,2, Miao Li Chee3, Riswana Banu3
1Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
Clinical kidney journal
|October 13, 2025
概括
2021年Creat-cys方程显示,在患有慢性病 (CKD) 的多民族亚洲人中,对全因死亡率的预测优越. 其他方程,如Creat-AS 2021和EKFCcreat提供了类似的心血管事件预测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 心血管医学 心血管医学
背景情况:
- 在慢性病 (CKD) 评估中,基于肌素的新型球透率 (GFR) 估计方程至关重要.
- 这些方程对预测死亡率和心血管事件的比较能力需要进一步研究.
研究的目的:
- 为了比较四个CKD流行病学协作 (CKD-EPI) 方程和三个欧洲功能联盟 (EKFC) 方程的预测性能.
- 评估他们在多民族亚洲人口中预测全因死亡率和心血管事件的能力.
主要方法:
- 对新加坡眼病流行病学基于人口的队列 (年龄在40-80岁的中国和印度成年人) 的分析.
- 通过国家疾病登记局联系确定死亡和发生的心血管事件.
- 多变量Cox比例危险回归和C-统计学用于预测性能比较.
主要成果:
- 与Creat-ASR 2009,Creat-AS 2021和EKFCcreat.相比,Creat-cys 2021在所有原因的死亡率方面表现出更好的预测能力.
- 在Creat-cys 2021,EKFCcreat和Creat-AS 2021之间没有观察到发生心血管事件预测的显著差异.
结论:
- 2021年Creat-cys在预测全因死亡率方面表现优于其他基于肌素的GFR方程.
- 在这个人群中,Creat-AS 2021和EKFCcreat为预测心血管事件提供了具有成本效益和可靠的替代方案.
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