甘油三指数和乳头甲状腺癌之间的关联在中国成年人甲状腺结节的甲状腺癌
Chunyan Song1, Miaomiao Ping1, Ling Lin1
1Clinical Laboratory, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China.
Frontiers in endocrinology
|October 13, 2025
概括
甘油三糖 (TyG) 指数与乳头甲状腺癌 (PTC) 的更高风险有关. 提升的TyG指数水平可以预测甲状腺结节患者的PTC发展.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 三甘油-葡萄糖 (TyG) 指数是胰岛素耐药性的公认标志物.
- 用TyG指数表示的胰岛素抵抗与通过增强的增殖和血管生成等途径增加癌症风险有关.
- 在中国人群中对TyG指数和乳头甲状腺癌 (PTC) 的研究是有限的.
研究的目的:
- 为了研究TyG指数与乳头甲状腺癌的患病率之间的联系.
- 确定TyG指数是否可以作为PTC的预测生物标志物.
主要方法:
- 一项涉及396名患者的横截面研究,这些患者接受了甲状腺结节的细针吸收.
- 使用多变量逻辑回归分析来评估TyG指数与PTC之间的关联.
- 进行了分层,相互作用和灵敏度分析,以证实研究结果的可靠性.
主要成果:
- 对于PTC的赔率比率在TyG指数的三分之一上升.
- 与最低的三位数 (T1) 相比,PTC的调整赔率比率为1.28 (T2) 和3.37 (T3).
- 亚组和灵敏度分析支持观察到的关联.
结论:
- 在患有甲状腺结节的患者中,TyG指数可能是预测乳头甲状腺癌的潜在生物标志物.
- 需要进一步进行大规模的前性研究来验证这些发现,并确认TyG指数对PTC的预测价值.
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