甲状腺功能低下症与妊娠糖尿病中代谢特征之间的关联
Sara Pinto1,2, Charlotte Nachtergaele3, Laura Croce4,5
1Assistance Publique - Hôpitaux de Paris (AP-HP), Avicenne Hospital, Paris 13 University, Sorbonne Paris Cité, Department of Endocrinology-Diabetology-Nutrition, Centre de Recherche en Nutrition Humaine - Ile de France (CRNH-IdF), Centre Spécialisé de l'Obésite Île-de-France Nord, Bobigny, France.
Frontiers in endocrinology
|October 13, 2025
概括
妊娠期糖尿病 (GDM) 妇女的妊娠期甲状腺功能低下症 (HG) 与较差的葡萄糖控制有关,由较高的HbA1c表示. 甲状腺刺激激素 (TSH) 水平与这些患者的胰岛素抵抗有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 怀孕并发症 怀孕并发症
背景情况:
- 甲状腺激素显著影响葡萄糖代谢.
- 妊娠糖尿病 (GDM) 和妊娠期间的甲状腺功能低下 (HG) 是常见的妊娠内分泌病.
- GDM和HG之间的潜在关联需要对它们的代谢相互作用进行调查.
研究的目的:
- 为了研究具有GDM和同时存在的HG的孕妇的代谢概况.
- 为了确定HG是否影响GDM患者的关键代谢标志物.
主要方法:
- 分析了1290名被诊断患有GDM的孕妇队列.
- 甲状腺刺激激素 (TSH) 和抗甲状腺氧化酶抗体水平在GDM诊断后进行测量.
- 代谢参数包括HbA1c,禁食血糖和HOMA-IR,根据HG (TSH≥4mUI/L) 的存在进行了评估.
主要成果:
- 9%的GDM患者 (117名女性) 呈现了HG.
- 与没有HG的女性相比,患有HG的女性HbA1c水平显著更高.
- TSH水平与HbA1c和对胰岛素抵抗的恒常模型评估 (HOMA-IR) 都显示出积极的关联.
结论:
- 在GDM患者中,同时存在的HG与HbA1c升高有关.
- 在这个队列中,较高的TSH水平与胰岛素抵抗性 (HOMA-IR) 的增加相关.
- 这些发现强调了甲状腺功能障碍在GDM怀孕中的代谢影响.
相关概念视频
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes Mellitus: Overview and Type I Subtype
4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K
Diabetes: Symptoms, Diagnosis, and Complications
2.1K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.1K
Overview of Carbohydrate Metabolism
3.2K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
3.2K
Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K


