体重调整的腰指数与心血管疾病之间的关联:系统性审查和元分析
Kelly Pimenta1,2, Edmore Madondo1, Ayesha Mukhopadhyay3
1Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, United States.
Frontiers in endocrinology
|October 13, 2025
概括
体重调整后的腰部指数 (WWI) 显示了与心血管疾病 (CVD) 风险增加的显著关联. 这种新型指标可能比传统措施更好地预测中心肥胖和心血管疾病.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 全球肥胖和心血管疾病 (CVD) 的增长带来了重大的公共卫生挑战.
- 像BMI和腰围 (WC) 这样的传统指标在预测心血管疾病风险方面存在局限性.
- 体重调整腰部指数 (WWI) 是一种新的指标,旨在更好地评估中心肥胖和相关风险.
研究的目的:
- 系统地审查和元分析体重调整腰部指数 (WWI) 与心血管疾病 (CVD) 之间的关联.
- 与传统指标相比,评估WWI作为中心肥胖和心血管疾病风险的潜在替代预测指标.
主要方法:
- 按照PRISMA指导方针进行系统的文献审查,注册于PROSPERO (ID CRD42024629861).
- 搜索了PubMed,Scopus和谷歌学者对第一次世界大战和CVD的观测研究.
- 对10项研究 (170,297名参与者) 的随机效应元分析,以汇总效应大小 (ORs/aHRs).
主要成果:
- 在第一次世界大战和心血管疾病风险增加之间发现了显著的积极关联 (合并OR: 1.33;95%CI: 1.17-1.48).
- 观察到适度的异质性 (I2 = 38.0%).
- 亚组分析表明,与中国研究相比,美国研究中的关联较强,横截面和队列设计之间没有显著差异.
结论:
- WWI显示出作为中央肥胖和心血管疾病风险评估的有价值的替代措施的潜力.
- 需要进一步的研究来探索人口特异性因素和潜在机制.
- 建议在多种不同人群中进行验证,并探索预防心血管疾病的临床应用.
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