在COVID-19后的病情和2型糖尿病患者中的核酸代谢异常及其与内分泌功能障碍的关联
Yalei Fan1, Xiaomin Xie2, Guirong Bai3
1The Second Clinical Medical School of Ningxia Medical University, Yinchuan, 750001, China.
Open medicine (Warsaw, Poland)
|October 13, 2025
概括
后COVID-19状态 (PCC) 破坏了核酸代谢,特别是 purin 和 pyrimidine 途径. 这种代谢失衡会影响内分泌功能,并且在2型糖尿病患者中可能会恶化.
科学领域:
- 内分泌学 在内分泌学.
- 代谢学 代谢学 代谢学
- 分子生物学分子生物学
背景情况:
- COVID-19 感染可能导致内分泌系统障碍.
- 后COVID-19状态 (PCC) 呈现出各种持续的症状.
- 核酸代谢在细胞功能和能量平衡中起着至关重要的作用.
研究的目的:
- 为了研究PCC患者核酸代谢模式的变化.
- 为了比较PCC患者与没有2型糖尿病 (DM) 之间的代谢概况.
- 探索核酸代谢与PCC中的内分泌功能障碍之间的关系.
主要方法:
- 超高性能液态染色体质谱法 (UPLC-MS) 用于分析血代谢物.
- 研究包括四组:PCC单独 (PCC-A),PCC与DM (PCC-DM),健康志愿者 (HV) 和DM.
- 进行了氨酸刺激试验,以评估激素分泌.
主要成果:
- 在各组之间观察到核酸代谢物中的显著差异.
- 与对照组相比,PCC患者的氨酸下调,而纯氨酸,胆氨酸和 uracil 则上调.
- 代谢物变化主要与核酸和胺酸代谢有关.
- 在PCC患者中注意到皮质醇和上腺皮质激素分泌量减少.
结论:
- 核酸代谢,包括de novo和救援途径,在PCC患者中显著受损.
- 这种损伤在患有同时存在的2型糖尿病患者中更为明显.
- 破坏核酸代谢有助于内分泌疾病和PCC中的细胞代谢失衡.
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