相关实验视频

Updated: Jan 15, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

对DBS对晚期PD患者认知功能影响的元分析

Yuxin Gai¹, Mengyi Qian², Guojian Lin³

¹Department of Neurology, Ningbo Yinzhou No. 2 Hospital, Ningbo, 315100, Zhejiang, China.

Open medicine (Warsaw, Poland)

|October 13, 2025

概括

深度大脑刺激 (DBS) 可能会对晚期帕金森病 (PD) 患者的认知功能产生负面影响,特别是在语音流方面. 虽然整体认知分数没有显著差异,但在PD DBS治疗中,特定领域需要谨慎.

科学领域:

神经学神经学
神经外科神经外科
认知科学认知科学

背景情况:

深度大脑刺激 (DBS) 已被确立为帕金森病 (PD) 运动症状的改善.
在晚期PD中DBS的认知影响仍然不清楚.
这项研究调查了DBS对高级PD患者认知功能的影响.

研究的目的:

系统地评估DBS对晚期帕金森病认知功能的影响.
综合来自随机对照试验 (RCT) 和队列研究的证据.
在PD中识别受DBS影响的特定认知领域.

主要方法:

在主要数据库 (PubMed,Embase等) 进行全面的文献搜索. 在2025年1月之前.
包括7个RCT和11个队列研究.
认知评估使用工具,如迷你精神状态检查 (MMSE) 和马蒂斯痴呆症评分表 (MDRS).

主要成果:

在DBS和最佳医疗疗 (BMT) 组之间,MMSE或MDRS得分没有显著的整体差异.
与 BMT 相比,在 DBS 组中观察到语音流性的显著下降 (P=0.03).
在信息处理,记忆,执行功能或视觉空间功能方面没有显著差异.

结论:

深度大脑刺激可能会对晚期帕金森病的认知功能构成风险.
语音流是一种特别易受DBS影响的认知领域.
需要进一步的研究来充分阐明DBS在PD的认知影响.

关键词:

帕金森病是帕金森氏症的一种疾病.认知功能认知功能深度大脑刺激刺激大脑语言功能语言功能语言功能进行元分析.

更多相关视频

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test

Published on: May 31, 2016

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

相关概念视频

Parkinson's Disease: Treatment

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...

Parkinson's Disease: Overview

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...