针对条形体的个性化时间干扰刺激减少了传感运动网络中的功能稳定性和动态连接性变化
Dongsheng Tang1, Lang Qin1, Longfei Hu1
1School of Kinesiology, Shenzhen University, Shenzhen, China.
Frontiers in neuroscience
|October 13, 2025
概括
针对条形体的时间干扰 (TI) 刺激降低了感觉运动网络的稳定性和动态功能连接的可变性. 这种非侵入性方法对运动网络障碍有希望.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 大脑网络动力学
背景情况:
- 传感器运动网络 (SMN) 的功能稳定性对于运动控制至关重要.
- 时间干扰 (TI) 刺激是一种非侵入性技术,用于调节像条纹体这样的深层大脑结构.
- TI刺激对电机网络动态功能稳定性的影响尚不清楚.
研究的目的:
- 研究TI刺激对传感运动网络功能稳定性和动态功能连接 (dFC) 的影响.
- 评估针对条形的TI刺激的安全性和耐受性.
主要方法:
- 一项对26名健康男性进行的双盲随机对照试验将TI刺激与假刺激进行了比较.
- 休息状态fMRI (rs-fMRI) 用于在刺激前和刺激期间测量大脑活动.
- 动态功能连接 (dFC) 和voxel-wise功能稳定性使用滑动窗口方法和肯德尔的一致系数进行了分析.
主要成果:
- 与假冒和基线相比,TI刺激显著降低了双边补充运动区域 (SMA) 区域的功能稳定性.
- TI刺激减少了右条纹体和左侧SMA之间的dFC变异性.
- 该程序是安全的,没有报告的不良认知或副作用和有效的失明.
结论:
- 向状体的TI刺激有效调节SMN稳定性和皮层-状体通路的dFC可变性.
- 这种非侵入性神经调节技术具有治疗运动网络障碍的潜力.
- 需要进一步的研究来探索其治疗应用.
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