莫亚莫亚病患者的加速大脑年龄:深度学习方法和与疾病严重程度的相关性
Wenjie Li1, Suhua Chen1, Xin Chen1
1Department of Neurosurgery, Peking University Third Hospital, Beijing, China.
Frontiers in neuroscience
|October 13, 2025
概括
莫亚莫亚病患者表现出加速的大脑衰老,较高的预测大脑年龄与疾病严重程度有关. 这种深度学习方法可能为莫亚莫亚病 (MMD) 的诊断和预后提供了一个新的生物标志物.
科学领域:
- 神经成像是一种神经成像.
- 人工智能的人工智能
- 放射学 放射学是一门学科.
背景情况:
- 莫亚莫亚病 (MMD) 是一种罕见的脑血管疾病,其特点是内动脉的渐进性狭窄.
- 准确评估MMD进展及其对大脑健康的影响对于患者管理至关重要.
研究的目的:
- 开发和验证一个深度学习框架 (DenseNet),用于预测MMD患者的大脑年龄.
- 调查预测的大脑年龄与MMD严重程度之间的相关性.
主要方法:
- 分析了432名MMD患者和565名对照组的无增强型MRI扫描.
- 使用DenseNet121架构进行大脑年龄预测.
- 预测的大脑年龄与时间年龄和MRA得分相关联.
主要成果:
- 与慢性年龄相比,MMD患者的预测大脑年龄显著更高 (37.9岁对35.8岁).
- 预测的大脑年龄与MRA分数呈正相关,表明大脑加快衰老与狭窄增加.
- 正常对照对象在预测和时间大脑年龄之间没有显著差异.
结论:
- 基于深度学习的脑年龄预测可以识别MMD中加速的大脑衰老.
- 大脑年龄作为MMD严重程度和进展的潜在成像生物标志物.
- 研究结果支持将大脑年龄预测用于个性化的MMD治疗策略.
更多相关视频
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
18.1K
12:50Lesion Explorer: A Video-guided, Standardized Protocol for Accurate and Reliable MRI-derived Volumetrics in Alzheimer's Disease and Normal Elderly
Published on: April 14, 2014
40.8K
相关概念视频
01:26Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
01:14Brain Imaging
663
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
663