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精神分裂症谱系障碍中的神经认知功能:对社区样本进行了20年的前性研究
Christine Mohn1, Anna-Karin Olsson2,3, Maivor Olsson-Tall4
1National Centre for Suicide Research and Prevention, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
这项为期20年的研究跟踪了精神分裂症谱系障碍 (SSD) 患者,发现口头学习和认知灵活性显著下降,这表明这些领域的大脑衰老加速.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 在精神分裂症谱系障碍 (SSD) 中的纵向神经认知研究通常集中在年轻的,第一次发作的患者身上.
- 关于老年SSD患者队伍的长期神经认知轨迹的数据有限.
研究的目的:
- 调查20年的神经认知轨迹在精神分裂谱系障碍 (SSD) 患者队列中,包括老年人.
- 为了评估二十年来认知功能的变化,在一个良好的特征 SSD 样本.
主要方法:
- 利用瑞典临床长期精神病研究 (CLIPS) 的数据进行了20年的随访.
- 在基线和20年后使用神经认知测试评估了28名精神分裂症谱系障碍 (SSD) 患者.
主要成果:
- 在20年内,参与者在认知灵活性,口头学习,口头保留记忆和口头智力功能方面出现了统计学上显著的恶化.
- 从基线到随访的所有显著变化都显示出很大的效果大小.
- 其他认知领域与基线相比没有显著变化.
结论:
- 虽然在20年内观察到整体的神经认知稳定性,但特定的语言领域表明精神分裂症谱系障碍 (SSD) 患者的衰老加速.
- 研究结果强调了评估不同SSD群体的长期认知变化的重要性.
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