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Regulation of Hormone Secretion01:19

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Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
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相关实验视频

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Author Spotlight: Investigating Islet Abnormalities and Function with a Pseudoislet Protocol
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芯片上的器官总结肠道岛屿轴对内分泌激素分泌调节剂的评估

Ji Sun1,2, Zhuhao Wu2, Jingbo Li1,2

  • 1Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

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一个新的器官芯片平台模拟了肠岛轴,以评估胆酸对激素分泌的影响. 这个系统准确地测量GLP-1和胰岛素释放,推动了代谢药物发现.

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科学领域:

  • 生物医学工程 生物医学工程
  • 内分泌学 在内分泌学.
  • 微流体学 微流体学

背景情况:

  • 器官芯片技术提供了先进的体外建模能力.
  • 肠岛轴及其在内分泌激素调节中的作用在基于芯片的系统中仍未得到充分探索.
  • 胆汁酸 (BAs) 是肠岛沟通和葡萄糖平衡的关键调节剂.

研究的目的:

  • 开发和验证一个器官在芯片上的平台,用于模拟肠道岛屿轴.
  • 评估胆汁酸对肠道激素和胰岛素分泌的影响.
  • 建立一种新的代谢药物发现系统.

主要方法:

  • 微流体芯片与多孔支架的制造,使用滴滴模板的负复制.
  • 在支架内共同培养肠道L细胞和胰腺β细胞,以形成均的球形.
  • 使用级联微流体系统来产生胆酸度梯度用于功能测试.

主要成果:

  • 该平台成功地回顾了肠道岛屿轴的特征.
  • 对GLP-1和胰岛素分泌的胆酸度进行了准确的评估.
  • 结果显示与现有文献一致,验证了平台的准确性.

结论:

  • 开发的器官芯片系统为研究肠道岛屿轴提供了强大的工具.
  • 这个平台可以精确评估胆汁酸在调节内分泌激素分泌中的作用.
  • 该系统具有加速代谢药物发现和研究的巨大潜力.