营养不良是常见的在患者使用像葡萄糖一样的-1激动剂在整体关节关节整形前的患者
Zachary Jodoin1, William H Young1, Daanish Sheikh1
1UT Health Science Center San Antonio, Department of Orthopaedics, San Antonio, TX, USA.
Arthroplasty today
|October 13, 2025
概括
经过全关节整形术 (TJA) 的葡萄糖类-1 (GLP-1) 受体激活剂使用者显示,手术前营养不良的比率明显更高. 在手术前,建议针对这个不断增长的患者群体进行有针对性的营养查.
科学领域:
- 整形外科手术 整形外科手术
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 肥胖率的上升和用于体重管理和糖尿病的GLP-1使用量的增加需要评估它们对手术患者的影响.
- 虽然GLP-1药物有效减肥,但可能会增加营养缺乏症的风险.
- 服用GLP-1受体激活剂的患者越来越多地接受选择性全关节节形成形术 (TJA).
研究的目的:
- 评估和比较接受选择性TJA的患者的术前营养状况,这些患者正在使用GLP-1受体激活剂,与那些没有使用GLP-1受体激活剂的患者相比.
- 在TJA群体中确定与GLP-1使用相关的特定营养缺陷.
主要方法:
- 165名接受选择性初级TJA的患者的回顾性图表审查.
- 对手术前营养标志物的分析,包括血红蛋白,白蛋白,总蛋白质,白蛋白前,,性酸酶和25-氧维生素D.
- 在GLP-1使用者和非使用者之间,营养不良率 (≥1缺乏) 和严重营养不良 (≥2缺乏) 的比较.
主要成果:
- 17.6%的患者是活跃的GLP-1用户.
- GLP-1使用者的营养不良率 (38%与8.8%) 和严重营养不良率 (17.2%与2.9%) 显著增加.
- 与非使用者相比,GLP-1用户的专蛋白,专前蛋白和总蛋白水平较低.
结论:
- GLP-1主动剂的使用在接受选择性TJA的患者中与术前营养缺乏症的增加密切相关.
- 这些发现突显出,在这个不断扩大的患者群体中,营养不良的风险很大.
- 手术前的营养查和优化应该是接受TJA的GLP-1用户的标准护理.
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