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肠-大脑轴的药理学调制:精神病生物在抑郁症治疗中的焦点

Zakirah Zainal Abidin¹, Zaw Myo Hein², Che Mohd Nasril Che Mohd Nassir³

¹School of Graduate Studies, Postgraduate Centre, Management and Science University, Shah Alam, Selangor, Malaysia.

Frontiers in pharmacology

|October 13, 2025

概括

肠道微生物组通过肠-大脑轴 (GBA) 影响主要抑郁症 (MDD). 用益生菌或其他干预措施调节肠道细菌可能有助于控制抑郁症,特别是治疗耐药的病例.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
精神病学是一个精神病学.

背景情况:

大型抑郁症 (MDD) 是一种复杂的疾病,受到生物,心理和环境因素的影响.
肠-大脑轴 (GBA),涉及肠-大脑通信,越来越多地被认为是通过肠道微生物群在MDD病原发生中的作用.
微生物群介导的机制是关键途径,将肠道失调与MDD联系起来.

研究的目的:

审查最近关于肠道微生物群在重大抑郁症 (MDD) 中的作用的发现.
综合MDD中肠-大脑轴 (GBA) 的临床前和临床研究的机制性见解.
探索微生物调制作为抑郁症辅助疗法的潜力.

主要方法:

在过去十年中进行的临床前和临床研究的叙事综述.
重点是从动物模型和转化人类数据的机械洞察力.
关键途径的分析,包括神经递质调节,免疫调节,迷走神经信号传递和SCFA代谢.

主要成果:

在MDD中,肠道失生症通常显示出减少的丁酸盐生产者和增加的促炎细菌.
这种失调与神经炎症,神经递质合成受损以及HPA轴失调有关.
诸如益生菌,益生菌,共生菌和精神生菌等干预措施在缓解抑郁症状方面表现有前途.

结论:

微生物调制为抑郁症管理提供了一种新的辅助策略,特别是在治疗耐药的病例中.
需要进一步严格的大规模试验来确认因果关系和优化干预措施.
未来的研究应该集中在微生物生物标志物和个性化,肠道向的精神卫生保健方法上.

关键词:

我们的肠道微生物群.大型抑郁症主要是抑郁症.后生物学的后生物.精神病生物制剂精神病生物制剂治疗疗法治疗疗法治疗疗法

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