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与MASLD相关的肝细胞癌中的免疫疗法耐药性:特殊的免疫微环境和肠道微生物群

Jie Jin¹, Kun Cheng¹, Mingrui Chen¹

¹Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.

International journal of biological sciences

|October 13, 2025

概括

与代谢功能障碍相关的脂肪性肝病 (MASLD) 相关的肝癌 (HCC) 正在增加,但免疫疗法效果较差. 了解免疫微环境和肠道微生物群是改善MASLD-HCC治疗的关键.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

与代谢功能障碍相关的脂肪性肝病 (MASLD) 是慢性肝病和肝细胞癌 (HCC) 的主要原因.
免疫疗法是一种标准的HCC治疗方法,在MASLD-HCC中显示出有限的疗效.
MASLD-HCC表现出一个独特的免疫微环境,涉及髓状细胞,淋巴细胞,血小板和肠道微生物群.

研究的目的:

在MASLD-HCC中审查免疫微环境和肠道微生物群.
为了确定影响MASLD-HCC.免疫疗法疗效的因素.
总结MASLD-HCC免疫疗法的潜在治疗点.

主要方法:

关于MASLD-HCC免疫学和肠道微生物组的当前研究的文献综述.
分析免疫细胞功能及其与肠道微生物群的相互作用.
影响免疫疗法反应的因素的综合.

主要成果:

MASLD-HCC具有一个独特的免疫微环境.
肠道屏障功能障碍和肠道微生物变化影响MASLD-HCC免疫力.
特定的免疫成分和肠道微生物群的相互作用有助于免疫疗法耐药性.

结论:

阐明免疫细胞和肠道微生物群之间的相互作用对于理解MASLD-HCC进展和免疫疗法耐药性至关重要.
针对免疫微环境和肠道微生物组,有望增强MASLD-HCC免疫疗法.
需要进一步的研究来开发有效的治疗策略来治疗MASLD-HCC.

关键词:

我们的肠道微生物群.肝细胞癌是肝细胞癌.免疫微观环境免疫微环境免疫疗法免疫疗法与代谢功能障碍相关的脂肪性肝病.

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