用以以患者为中心的尺度来定义下尿道症状的男性的国际前列腺症状评分的最小重要差异
Laura Wiemer1,2, Walter Lehmacher3, Sandra Schönburg4,5
1Department of Urology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
European urology open science
|October 13, 2025
概括
在患有下泌尿道症状 (LUTS) 的男性中,国际前列腺症状评分 (IPSS) 的最小重要差异 (MID) 为5.26点. 这一发现有助于临床医生解释治疗有效性,并指导未来的LUTS研究.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床试验 临床试验
- 医疗信息学 医疗信息学
背景情况:
- 国际前列腺症状评分 (IPSS) 的最小重要差异 (MID) 对于解释下尿道症状 (LUTS) 的治疗结果至关重要.
- 有限的研究已经确定了IPSS MID,需要进一步调查.
研究的目的:
- 为了确定男性体验LUTS的IPSS MID.
- 利用随机对照试验 (RCT) 的数据来评估基于应用程序的 LUTS 干预.
主要方法:
- 从一项涉及患有LUTS (良性前列腺增生,膀过活或两者) 的男性的RCT数据的二次分析.
- 参与者使用了Kranus Lutera应用程序12周,并完成了IPSS和患者全球变化印象 (PGIC) 调查问卷.
- 在PGIC上报告"微小改善"的男性,MID被计算为IPSS的平均变化.
主要成果:
- 计算的IPSS MID为5.26分 (95% CI为4.38-6.13). 这是一个非常好的方法.
- 与那些有中度症状 (4.00) 的男性相比,在具有严重基线症状 (8.23) 的男性中观察到更高的MID.
- 由于来自单个RCT和小子组样本大小的数据,一般化可能受到限制.
结论:
- 这些发现为临床医生评估LUTS治疗结果提供了有价值的参考.
- 该研究强调,需要在多样化的群体中进行进一步的研究,以提高IPSS MID的通用性和外部验证.
- 结果可以为LUTS干预措施的未来临床试验设计提供信息.
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