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Updated: Jul 3, 2026

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在Crl:CD(SD) 鼠身上进行了为期28天的 puberulic 酸亚急性毒性研究

Kohei Matsushita1, Genichiro Tsuji2, Hirotoshi Akane1

  • 1Division of Pathology, Center for Biological Safety and Research, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-shi, Kanagawa 210-9501, Japan.

Journal of toxicologic pathology
|October 13, 2025
PubMed
概括

红酵母大米产品中的污染物酸 (PA) 在老鼠中引起脏损伤. 毒性大多是可逆的,没有观察到的不良影响水平为1mg/kg/day.

关键词:
贝尼-科吉 (Beni-Koji) 是一个有功能性声明的食品.健康食品产品健康食品的产品毒性 毒性 毒性青春期的青春酸是什么意思红酵母大米的红酵母大米

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...