人类母乳衍生的5'-UMP促进了热生成和线粒体生物生成,以改善肥胖症
Ling Zhang1,2, Zhou Peng1, Caiyu Lin1
1Endocrinology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in nutrition
|October 13, 2025
概括
人类母乳含有尿素5'-单酸盐 (5'-UMP),是一种通过促进热生成和线粒体功能来对抗肥胖的代谢物. 这种乳制品化合物显示出作为儿童肥胖的安全治疗方法的希望.
科学领域:
- 代谢学 代谢学 代谢学
- 营养生物化学 营养生物化学
- 儿科内分泌学 儿科内分泌学
背景情况:
- 儿童肥胖干预措施面临着传统方法的挑战.
- 人类牛奶的生物活性代谢物可能会减轻肥胖风险.
- 尿素5'-单酸盐 (5'-UMP) 在脂质代谢和热生成中的作用在很大程度上尚未被探索.
研究的目的:
- 鉴定人类胆汁中与肥胖相关的代谢物.
- 在临床前模型中研究5'-UMP对抗肥胖的影响.
- 评估5'-UMP对脂质代谢和线粒体功能的影响.
主要方法:
- 从肥胖和健康母亲的乳酪中获得的非向代谢.
- 使用斑马鱼幼虫的体内研究和使用人类前脂质细胞的体内研究.
- 通过染色和光成像来评估脂质积累和线粒体功能.
主要成果:
- 在肥胖的母亲身上观察到皮里米丁代谢的改变,包括改变的5'-UMP水平.
- 5'-UMP在斑马鱼中显示出安全性,并在肥胖模型中显著降低脂质积累.
- 在脂肪细胞中,5'-UMP增强了线粒体呼吸,生物发生和关键热生成基因的表达 (PGC1-UCP1).
结论:
- 孕产妇的肥胖会改变人乳代谢组.
- 牛奶衍生的5'-UMP促进热生成和线粒体活动,减少实验模型中的肥胖.
- 5'-UMP是一种潜在的安全,乳制品治疗儿童肥胖的候选药物.
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