怀孕前的体重指数和后代的神经行为发展:一个出生队列研究
Peng Sun1, Youdan Hu2, Min Wei1
1Maternity and Child Healthcare Hospital of Nanshan District, Shenzhen, China.
Frontiers in nutrition
|October 13, 2025
概括
怀孕前母亲的超重或肥胖与儿童的发育迟缓有关,特别是在沟通和解决问题的技能方面. 这种风险在男孩中更为明显,这凸显了怀孕前体重管理的重要性.
科学领域:
- 儿科神经发育 儿童神经发育
- 孕产妇健康与营养
- 环境流行病学环境流行病学
背景情况:
- 儿童的神经发育障碍 (NDD) 很普遍,需要早期干预.
- 产前环境因素对NDD的影响需要进一步调查.
- 孕前母亲的体重指数 (BMI) 是一个关键的产前因素,影响后代的神经发育.
研究的目的:
- 研究母亲怀孕前的BMI与后代的神经行为发展之间的纵向关联.
- 确定受孕前母亲BMI影响的特定神经发育领域.
- 探索这种协会中潜在的性别特异性影响.
主要方法:
- 利用了深出生队列 (2255对母婴对) 的数据.
- 通过问卷收集母亲怀孕前的BMI和社会人口统计数据.
- 评估儿童神经行为发育 (1-36个月) 使用年龄和阶段问卷,第三版 (ASQ-3).
- 使用统计分析的概括估计方程.
主要成果:
- 母亲超重/肥胖 (队列中的9.0%) 显著增加了沟通 (aOR=1.55) 和问题解决 (aOR=1.44) 延迟的风险.
- 性别分层分析显示,男孩在解决问题 (aOR=1.60) 和个人-社会领域 (aOR=1.43) 中存在显著的关联.
- 体重不足和正常的BMI类别没有显著增加发育迟缓的风险.
结论:
- 孕前母亲的超重/肥胖是后代神经行为发育迟缓的独立风险因素.
- 观察到的性别特异性影响表明对男性和女性神经发育的不同影响.
- 怀孕前的体重管理对于针对NDD的初级预防策略至关重要.
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