美国成年人的氧化平衡得分和过敏性鼻炎之间的关联:一个横截面研究
Yanhua Tian1, Wenbo Sun2, Jijun Song1
1Department of Otorhinolaryngology, Zhoukou Central Hospital, Zhoukou Medical Science Research Center, Zhoukou, China.
Frontiers in nutrition
|October 13, 2025
概括
较高的氧化平衡分数 (OBS),反映出更多的亲氧化剂暴露,与美国成年人过敏性鼻炎 (AR) 的几率增加有关. 这表明OBS可能是AR研究中有用的标记物.
科学领域:
- 环境健康 环境健康
- 营养流行病学 营养流行病学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激越来越被认为是过敏性鼻炎 (AR) 发展的一个因素.
- 使用复合指标对氧化应激和AR进行的人口水平研究是有限的.
- 本研究探讨了美国成年人口中氧化平衡评分 (OBS) 和AR之间的关联.
研究的目的:
- 研究美国成年人中氧化平衡评分 (OBS) 和过敏性鼻炎 (AR) 之间的关联.
- 评估饮食和生活方式对抗氧化剂和抗氧化剂暴露对AR患病率的影响.
- 确定OBS是否可以作为AR流行病学中与饮食相关的氧化还原平衡的复合标记.
主要方法:
- 分析了2005-2006年全国健康和营养检查调查 (NHANES) 的数据,其中包括1491名美国成年人.
- 基于16种饮食和4种生活方式因素计算OBS,分析连续和四分位数.
- 使用多变量逻辑回归,受限立方线模型和调查加权分析,进行敏感性和子组分析,评估与AR的关联.
主要成果:
- 较高的总和饮食OBS显着与过敏性鼻炎 (AR) 的几率增加有关.
- 总OBS的每个单位增加与AR几率增加2%相关 (OR=1.02),每个SD增加与19%的增加相关 (OR=1.19).
- 观察到剂量反应关系,总和饮食OBS的最高四分位数与最低四分位数相比显示出明显更高的AR几率.
结论:
- 增加的OBS,特别是来自饮食因素,与在全国代表性的美国成年人样本中增加AR的几率有关.
- 这些发现表明,OBS是AR流行病学背景下与饮食相关的氧化还原平衡的实用复合标记.
- 该研究强调了氧化平衡在过敏性鼻炎的发展和进展中的潜在作用.
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