脊椎瘤学临床试验患者招募的差异
Emily Xu1, James M Schuster1, Anish Butala2
1Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Neuro-oncology practice
|October 13, 2025
概括
脊椎瘤学的临床试验显示,多样性方面取得了进展,但仍然存在显著的种族,种族和地理差异. 参与者人口统计数据的报告差距阻碍了确保在癌症研究中公平招生的努力.
科学领域:
- 在瘤学瘤学.
- 临床试验 临床试验
- 健康 公平 卫生 公平
背景情况:
- 临床试验中亚群体代表性不足导致数据偏差和医疗保健不平等.
- 脊椎瘤学试验在报告和参与者代表性方面面临挑战.
- 地理和社会经济因素影响试验人口统计.
研究的目的:
- 评估脊柱瘤学试验中的报告标准.
- 评估不同的人口统计数据中的参与者代表性.
- 分析地理和社会经济趋势对试验多样性的影响.
主要方法:
- 在ClinicalTrials.gov (2000-2023) 上注册的42项已完成的脊椎瘤学试验的分析.
- 将5679名参与者的人口统计数据与国家脊髓瘤发病率数据进行比较.
- 与四级护理中心接受脊椎瘤手术的患者的人口数据的比较.
主要成果:
- 只有50%的试验报告了种族,28.6%报告了种族.
- 与全国发病率相比,黑人,美洲印第安人/阿拉斯加原住民和西班牙裔患者的代表性明显不足.
- 与手术患者群体相比,黑人和女性患者的代表性不足.
- 2020年后启动的试验显示,少数群体的代表性有所改善.
- 试验场所集中在大都市地区,地理差距很大.
结论:
- 尽管取得了进展,但在脊髓瘤学试验中仍然存在显著的种族,种族和地理差异.
- 参与者人口统计数据的不完整报告阻碍了入学公平的评估.
- 需要进一步努力,以确保临床研究中的多样性和公平代表性.
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