患有后COVID-19综合征和MTHFR基因和Prothrombin II突变的患者的内皮功能障碍
David Martinez Juarez1,2, Omar Gomez-Monterrosas3, Francisco Zamora Rosales4
1Radiology/Cardiovascular Imaging, Christus Muguerza Hospital Betania, Puebla, MEX.
Cureus
|October 13, 2025
概括
这项案例研究强调了基因突变,包括MTHFR C677T和前列血因子II G20210A,结合血小板过敏反应,可能使个人在COVID-19感染后易患内皮功能障碍和冠状动脉微血管功能障碍.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19综合征涉及持续的心血管症状,如胸痛和疲劳.
- SARS-CoV-2 感染可以引起内皮炎和血管炎症,可能导致冠状动脉微血管功能障碍.
- 遗传因素,如血栓过敏症,可以加剧内皮损伤.
研究的目的:
- 报告一个COVID-19后综合征病例与冠状动脉微血管功能障碍.
- 调查遗传突变和血小板过敏反应在长期COVID心血管症状的发病过程中的作用.
- 讨论预防性抗凝剂在特定高风险患者中的潜在益处.
主要方法:
- 一个25岁的女性在COVID-19后患有持续的胸痛的病例报告.
- 心声图和心磁共振成像 (CMRI) 用于心肌评估.
- 冠状动脉CT血管造影 (CCTA) 排除阻塞性冠状动脉疾病.
- 血液学评估,包括血小板聚合研究和对MTHFR C677T和原血因子II G20210A突变的基因检测.
主要成果:
- 患者表现出严重的胸痛和呼吸障碍,心声回声检查结果异常,以及CMRI上肌肉心脏干预的证据.
- 基因检测显示同卵性MTHFR C677T和异卵性前素因子II G20210A突变,以及血小板高反应性.
- 冠状动脉CT血管学排除了阻塞性冠状动脉疾病,这表明微血管病因.
- 患者在服用抗血小板药物,维生素和抗血管药物的组合后,临床改善.
结论:
- 患有特定遗传倾向 (MTHFR C677T,前列血因子II G20210A) 和血小板过敏反应的患者可能面临SARS-CoV-2感染后内皮功能障碍和冠状动脉微循环障碍的风险增加.
- 个体化风险-益处评估可能需要考虑在特定的COVID-19后患有这些风险因素的患者中预防性抗凝药.
- 这一案例强调了病毒感染,遗传易感性和血管健康在长期COVID症状发展中的复杂相互作用.
关键词:
心脏磁共振成像 (CMRI) 是一种心脏磁共振成像技术.冠状动脉微血管功能障碍 (CMD)内皮质功能障碍 在内皮质功能障碍遗传性血栓友爱症是一种遗传性血栓友爱症.微血管性心痛是什么意思这就是MTHFR基因.后COVID-19综合征的发生.前列腺血因子II c97g>a 突变这是SARS-CoV-2病毒.粘性血小板综合征是什么?更多相关视频
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