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相关实验视频

Updated: Jan 15, 2026

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

Published on: June 23, 2022

一份关于生物微流体微研磨的协议指南.

Hannah L Viola^1,2, Vishwa Vasani^1,3, Shuichi Takayama^1,4

¹The Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.

|October 13, 2025

概括

本研究介绍了微型削的实用协议,计算机数控 (CNC) 加工技术,以制造芯片上的器官. 这种方法增强了快速原型设计和复杂的3D特征的创建,以更好地进行生理模型.

关键词:

这是CNC加工.微型磨粉机微型磨粉机微流体学微流体学器官在芯片上的器官在 PDMS 造中使用 PDMS.快速原型制造快速原型制造

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$Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics$

Fabrication of Refractive-index-matched Devices for Biomedical Microfluidics

Published on: September 10, 2018

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Computer Numerical Control Micromilling of a Microfluidic Acrylic Device with a Staggered Restriction for Magnetic Nanoparticle-Based Immunoassays

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Published on: June 23, 2022

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

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科学领域:

生物技术是生物技术.
制造业工程制造工程
医疗设备制造业医疗设备制造业

背景情况:

微研磨是一种减法制造技术,用于从各种基板中创建微尺度的3D特征.
与传统方法相比,它为生物微流体设备和主模具的快速原型设计提供了优势.
它在芯片器官制造中的应用是有限的,因为需要专门的计算机数值加工 (CNC) 专业知识.

研究的目的:

为基于微型造的芯片器官制造提供实际指导方针.
为了解决应用CNC技术用于芯片器官开发的知识差距.
为了促进复杂的3D特征的设计和原型设计,以改善生理总结.

主要方法:

微加工的详细协议,包括工具路径优化.
使用SolidWorks和Fusion软件进行模型设计和工具路径生成的工作流程.
一步一步的指南涵盖模型设计,微型削,设备组装和细胞培养.

主要成果:

展示器官在芯片制造的微型削.
成功设计和制造用于人类呼吸道芯片上的主模具.
在最近的出版物中,制造模具的验证.

结论:

微型削可以有效地扩展到芯片上器官的制造.
这种技术提高了快速设备原型制造的能力.
它可以设计更复杂的3D特征,更好地模仿人类生理学.