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在天生的免疫力中化:将代谢重编程与免疫调节联系起来

Reham Atallah¹, Juergen Gindlhuber², Akos Heinemann¹

¹Otto Loewi Research Center for Vascular Biology, Immunology and Inflammation, Division of Pharmacology, Medical University of Graz, Graz, Austria.

Frontiers in immunology

|October 13, 2025

概括

酸盐是细胞能量生产中的关键代谢物,也调节天生的免疫细胞. 这篇评论探讨了简要的简要.

科学领域:

生物化学生化学
免疫学免疫学免疫学
细胞的新陈代谢

背景情况:

酸盐是三碳酸 (TCA) 循环中的关键代谢物,并将其连接到电子输送链 (ETC) 进行腺三酸盐 (ATP) 生产.
新出现的证据突出显示了酸盐在调节免疫细胞功能的重要作用.
酸盐会影响诸如活性氧物种 (ROS) 生产,低氧诱导因子-1α (HIF-1α) 稳定,蛋白质化和通过酸盐受体1 (SUCNR1) 进行细胞间通信等过程.

研究的目的:

简要介绍苏酸在先天性免疫细胞中的调节功能.
突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出突出
确定与免疫中苏酸盐相关的研究缺口和潜在的治疗点.

主要方法:

文献综述,重点关注酸盐在天生的免疫力中的作用.
分析涉及苏酸盐的机制,包括ROS产生,HIF-1α稳定,蛋白质苏化和SUCNR1信号传递.
检查酸盐在炎症中的双重作用 (促炎或抗炎作用).

主要成果:

苏酸在炎症中表现出取决于情境的双重作用,具有支持或抗炎作用.
酸盐会影响与先天性免疫细胞免疫反应相关的关键细胞过程.
苏酸盐在天生的免疫力中的作用机制是多方面的,涉及各种信号通路.

结论:

酸盐是先天免疫细胞功能的关键调节剂,对炎症过程有重大影响.
了解酸盐在免疫中的机制为新的治疗策略提供了潜力.
需要进一步的研究来充分阐明酸盐在天生的免疫力中的复杂作用和治疗潜力.

关键词:

缺氧诱导因子-1α (HIF-1α)这是一种炎症炎症炎症炎症.天生的免疫细胞是天生的免疫细胞.反应性氧物种 (ROS) 是一种反应性氧物种.顺酸是什么意思苏酸脱酶 (SDH) 的作用.苏酸受体1 (SUCNR1) 的存在葡萄糖化葡萄糖化

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