怀孕期间自身抗体的产生:与mRNA BNT162b2免疫接种,活跃的COVID-19和子宫前的关系
Mauro César da Silva1, George Tadeu Nunes Diniz2, Maria Júlia da Silva Correia1
1Laboratory of Immunogenetics, Department of Immunology, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Brazil.
Frontiers in immunology
|October 13, 2025
概括
COVID-19 BNT162b2疫苗没有增加孕妇自身抗体的产生. 与未接种疫苗的组相比,接种疫苗的妇女表现出较少的自身抗体,这表明怀孕期间mRNA疫苗不会增加自身免疫风险.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 孕产妇健康 孕产妇健康
背景情况:
- 人们担心mRNA疫苗的潜在自身免疫副作用.
- 巴西的孕妇和产后妇女优先使用BNT162b2 (Comirnaty) 疫苗.
- 评估关于怀孕期间自身免疫反应的疫苗安全性至关重要.
研究的目的:
- 为了评估与BNT162b2.2.接种疫苗的孕妇自身抗体的生产.
- 为了比较接种疫苗和未接种疫苗的孕妇之间的自身抗体频率,包括患有COVID-19或子宫前的孕妇.
- 将接种疫苗的孕妇与健康的非孕妇对照进行比较.
主要方法:
- 一项涉及273名孕妇 (18-48岁) 和47名非孕妇对照的研究.
- 参与者被分为四组:健康的接种疫苗,健康的未接种疫苗,COVID-19阳性和子前期.
- 使用HEp-2套件检测到自身抗体.
主要成果:
- 接种疫苗的孕妇的自身抗体产生频率明显低于未接种疫苗的孕妇.
- 在接种疫苗的孕妇和健康对照人群之间,没有发现自身抗体模式的显著差异.
- 健康的非孕妇对照显示了特定自身抗体模式 (AC-4,AC-24) 的更高频率.
结论:
- 接种BNT162b2疫苗似乎不会增加孕妇自身免疫反应的风险.
- 接种疫苗的个体中较低的自身抗体频率可能表明有益的免疫调节.
- 需要进一步研究自身抗体的产生和与怀孕相关的自身免疫性疾病.
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