利用骨髓系衍生抑制细胞的双重免疫调节功能,重塑骨关节炎治疗的炎症微环境
Zili Guo1,2, Tao Chen3,4,5,6, Xuehuan Wen7
1Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, 610031, PR China.
Materials today. Bio
|October 13, 2025
概括
矛盾的是,骨髓系衍生抑制细胞 (MDSCs) 在骨关节炎 (OA) 中驱动炎症和修复. 一个新的生物材料系统控制了MDSC的可塑性,将关节环境从亲炎性转变为亲再生性,减少OA损伤.
科学领域:
- 免疫学 免疫学 免疫学
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
背景情况:
- 骨关节炎 (OA) 的发病过程涉及复杂的免疫失调,特别是因特乐金-17 (IL-17) /T助手17 (Th17) 细胞介导的炎症和受损的组织修复.
- 骨髓原抑制细胞 (MDSC) 已经成为关键参与者,在加剧炎症和潜在地促进OA关节内的组织再生方面发挥双重作用.
研究的目的:
- 阐明MDSCs在骨关节炎发病过程中的多方面的作用.
- 开发和评估一种基于生物材料的新型治疗策略,以调节OA治疗的MDSC功能.
主要方法:
- 研究了OA小鼠模型中的MDSC功能,评估它们对IL-17通路和白细胞招募的影响.
- 开发了一种生物响应的水凝微球系统,将转化生长因子β1 (TGF-β1) 和抗IL-1β抗体封装在半孔纳米粒子 (MSN) 中.
- 在OA模型中评估了生物材料系统在调节免疫微环境和恢复关节完整性方面的治疗疗效.
主要成果:
- 在OA小鼠中,关节内MDSC的使用加剧了IL-17驱动的炎症和白细胞透.
- MDSCs表现出可塑性,可调节阿尔金酶-1以促进M2巨细胞的两极分化和再生位.
- 开发的生物材料系统成功地抑制了Th17细胞的扩张,同时增强了M2巨细胞的两极化和chondrogenesis.
- 在OA模型中,治疗显著减轻了软骨侵蚀,并恢复了关节完整性.
结论:
- 在OA中,MDSCs充当双功能性免疫调节器,有助于炎症和修复.
- 精密生物材料引导免疫调节,通过工程MDSC可塑性,为OA提供了一个有前途的治疗策略.
- 这种方法为退行性关节疾病中微环境重塑提供了蓝图.
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