相关实验视频

Updated: Jan 15, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

综合的多omics分析显示TMEM147是LUAD中的免疫抑制性预后生物标志物

Lei Ding¹, Yi Ding²

¹Medical Records Room, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, 150040, China.

Biochemistry and biophysics reports

|October 13, 2025

概括

细胞内膜网膜蛋白TMEM147通过增强细胞迁移,入侵和增殖,促进肺腺癌 (LUAD) 的进展. 对于LUAD患者来说,TMEM147可以作为预后生物标志物和治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

内质网膜 (ER) 膜蛋白TMEM147与肺腺癌 (LUAD) 进展有关,但其具体作用尚未完全理解.
了解TMEM147的功能对于确定针对LUAD的新治疗策略至关重要.

研究的目的:

研究TMEM147在LUAD进展中的功能作用.
评估TMEM147作为潜在的预后生物标志物和LUAD治疗点.

主要方法:

对TCGA和GEO数据集的生物信息分析,以评估TMEM147表达和预后意义.
基因本体学 (GO) 和基因和基因组的京都百科全书 (KEGG) 路径丰富分析.
在TMEM147沉默后进行体外功能测试,包括迁移,入侵和扩散测试.
转录因子结合预测和免疫细胞透分析.

主要成果:

TMEM147在LUAD组织中显著上调,并与患者的存活率差相关.
TMEM147的表达影响瘤免疫微环境,并与核糖蛋白生物发生和氧化酸化 (OXPHOS) 途径有关.
沉默TMEM147显著抑制了LUAD细胞的迁移,入侵和增殖.
确定FLI1是TMEM147.7的一个关键的转录调节器.

结论:

TMEM147显著促进了LUAD的进展.
TMEM147显示出作为LUAD预后生物标志物的潜力.
向TMEM147可能为肺腺癌提供一种新的治疗策略.

关键词:

生物信息学分析癌症的免疫系统透到癌症中.肺部腺癌瘤是肺部腺癌.预测生物标志物预测生物标志物在TMEM147中,我们可以使用TMEM147.

更多相关视频

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...