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相关概念视频

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
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由葡萄糖皮质类药物诱导的白内障

Yu-Feng Jian1, Jing-Shang Zhang1, Xiu-Hua Wan1

  • 1Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Key Laboratory of Ophthalmology and Vision Science, Beijing, 100730, People's Republic of China.

Clinical ophthalmology (Auckland, N.Z.)
|October 13, 2025
PubMed
概括

葡萄糖皮质醇诱导的白内障 (GIC) 是长期使用类固醇治疗自身免疫性疾病的主要并发症. 了解GIC的理解GIC的理解

科学领域:

  • 眼科和药理学 眼科和药理学
  • 分子生物学和遗传学分子生物学和遗传学
  • 流行病学和公共卫生.

背景情况:

  • 葡萄糖皮质类药物 (GCs) 对于治疗非传染性脑膜炎和自身免疫性疾病至关重要.
  • 慢性GC的使用经常导致危及视力的并发症,尤其是葡萄糖皮质激素诱导的白内障 (GIC).
  • GIC显著损害视力敏度,光恐惧症和整体生活质量.

研究的目的:

  • 提供对GIC分子病原,流行病学和临床管理的全面审查.
  • 综合当前的证据来解决GC治疗悖论.
  • 为未来的GIC临床管理建立强大的框架.

主要方法:

  • 系统审查和综合当前的科学证据.
  • 在接受全身皮质类固醇治疗的患者眼部并发症的流行病学分析.
  • 对基因病理学发现和GIC的分子机制的审查.
  • 对白内障发生的风险分层模型的分析.

主要成果:

  • 在接受系统性皮质类固醇治疗超过60天的患者中,超过50%的患者经历了眼部并发症,其中白内障 (36%) 和绿内障 (16%) 是最常见的.
  • GIC涉及与氧化应激,EMT,维门丁失调,Na+/K+-ATPase抑制,亡和ER应激相关的后部亚囊的不透明性.
关键词:
葡萄糖皮质类药物葡萄糖皮质类药物诱导的白内障干预干预干预干预干预干预

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  • GIC的主要风险因素包括累积的GC剂量,治疗持续时间和服用途径 (口服>局部>静脉内).
  • 结论:

    • GIC是基本的GC治疗的普遍和衰弱的并发症.
    • 了解分子病原和流行病学模式对于有效管理至关重要.
    • 未来的干预措施应侧重于抗氧化剂,向疗法,先进的药物输送和GC节约剂.