糖化和糖在醇中的变化产生了有希望的益生菌类效应
Tong Sun1, Jingyi Yang1, Lili Lu1
1School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Current research in food science
|October 13, 2025
概括
铁醇糖化物表现出增强的益生菌效应,促进有益的肠道细菌,如乳酸菌和Bifidobacteria. 特别是泰罗索尔β-galactoside,支持Akkermansia和有益的食人,表明其作为一种新型食品添加剂的潜力.
科学领域:
- 食品科学与技术 食品科学与技术
- 微生物学 微生物学
- 营养保健品 营养保健品
背景情况:
- 化合物在食品中普遍存在,它们的糖化可以改善生物活性.
- 基的糖化增强了它们的物理化学特性和生物可用性.
- 了解肠道微生物对酸甘的反应对于食品添加剂的开发至关重要.
研究的目的:
- 评价泰罗斯醇及其糖化物 (沙利德化物和泰罗斯醇β-光化物) 的益生菌性质.
- 为了研究铁醇糖化对肠道细菌组成和代谢物概况的影响.
- 确定潜在的新型食品添加剂,对肠道微生物群产生有益影响.
主要方法:
- 给C57BL/6J小鼠注射铁醇,沙利德化物和铁醇β-银化物.
- 对肠道细菌种群的分析,包括益生菌和共生菌.
- 代谢分析分析,以评估宿主和微生物代谢物的变化.
- 铁醇及其糖化物之间的效应比较.
主要成果:
- 与tyrosol相比,这两种tyrosol糖化物都显示出增强的益生菌效应.
- 沙利德化物促进了乳酸菌的生长;铁醇β-银化物促进了Bifidobacteria和Akkermansia的繁殖.
- 泰洛索尔β-银酸激活了降解粘液的共生体,并抑制了与疾病有关的细菌.
- 代谢分析揭示了不同的模式,在糖化组中含有丰富的异黄.
结论:
- 铁醇的甘化显著改变了肠道细菌的组成和代谢物概况.
- 泰罗索尔β-银酸盐表现出优越的益生菌功能,包括促进有益的细菌和抑制病原体.
- 泰罗索尔β-银酸是作为一种用于肠道健康调节的新型食品添加剂的有希望的候选者.
更多相关视频
11:25Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
Published on: October 4, 2017
7.0K
11:31High-throughput Screening of Recalcitrance Variations in Lignocellulosic Biomass: Total Lignin, Lignin Monomers, and Enzymatic Sugar Release
Published on: September 15, 2015
10.4K
相关概念视频
Oligosaccharide Assembly
3.5K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
3.5K
Protein Glycosylation
9.3K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
9.3K
Biosynthesis of Polysaccharides
552
Polysaccharides such as glycogen and starch are synthesized from nucleoside diphosphate sugars, primarily uridine diphosphate glucose (UDPG) and adenosine diphosphate glucose (ADPG). These activated glucose donors act as key intermediates in carbohydrate metabolism and biosynthesis. UDPG primarily involves glycogen synthesis in animals and many bacteria, while ADPG plays a fundamental role in starch synthesis in plants and certain bacteria.UDPG is formed when glucose-1-phosphate reacts with...
552
Fates of Pyruvate
10.4K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
10.4K
Proteoglycans
4.7K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.7K
Glucose Absorption Into the Small Intestine
35.0K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
35.0K
