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-联合暴露和VEGFA基因多态性对功能障碍的相互作用影响:基因与环境相互作用研究
Yaotang Deng1,2, Yunman Wen2, Weixia Duan1
1Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China.
血管内皮生长因子a (VEGFA) 的基因变异改变了因 (Pb) 和 (Cd) 暴露而导致功能障碍的风险. 识别这些VEGFA多态可能有助于针对高风险人群进行预防.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 遗传学 是一个遗传学.
背景情况:
- (Pb) 和 (Cd) 是持久性环境污染物,与功能障碍有关.
- 基因与环境的相互作用在病的发病过程中起着至关重要的作用.
研究的目的:
- 调查血管内皮生长因子a (VEGFA) 基因多态化是否会改变Pb和Cd暴露与功能障碍风险之间的关联.
- 在重金属诱导的损伤的背景下检查基因环境相互作用.
主要方法:
- 对Pb-Cd炼厂的408名工人的横截面研究.
- 使用诱导合等离子体质谱法 (ICP-MS) 测量血液和尿液金属.
- 使用基因模型和与Pb和Cd暴露的相互作用分析分析了VEGFA多态 (rs3025010,rs10434,rs833061).
主要成果:
- 血 (BPb) 和尿 (UCd) 被确定为功能障碍的危险因素 (ORs 1.40-3.46).
- 在VEGFA多态 rs3025010和rs10434与Pb-Cd同时暴露之间发现了显著的相互作用.
- 具体的相互作用包括BPb × rs3025010 (主导模型) 和Pb/Cd × rs10434 (附加和递归模型).
结论:
- 在VEGFA多态 (rs3025010,rs10434) 和Pb-Cd联合暴露之间显著的基因环境相互作用有助于功能障碍.
- 对这些VEGFA多态的查可以识别更高风险的个体,从而实现有针对性的预防策略.
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