高强度间歇训练与中等强度持续训练对2型糖尿病炎症和代谢生物标志物的可行性和初步影响:试点随机对照试验
Sahar Alizadeh1, Mohsen Avandi1, Brandon G Fico2
1Sport Science Department, Faculty of Humanities, Semnan University, Semnan, Iran.
Journal of diabetes and metabolic disorders
|October 13, 2025
概括
高强度间歇训练 (HIIT) 可能会降低2型糖尿病 (T2DM) 患者的calprotectin水平. 这项试点研究发现HIIT是可行的和安全的,这表明未来的试验可能会调查其对心血管的益处.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
背景情况:
- 血calprotectin的升高与2型糖尿病 (T2DM) 中心血管风险增加有关.
- 生活方式干预,如运动,可能有助于调节calprotectin水平.
- 这项试点研究探讨了没有现有心血管疾病的T2DM患者的运动干预措施.
研究的目的:
- 评估未来全面试验的可行性,比较高强度间歇训练 (HIIT) 和中等强度持续训练 (MICT).
- 评估HIIT与MICT对T2DM患者的calprotectin水平的影响.
- 在这个人群中确定HIIT和MICT的安全性和耐受性.
主要方法:
- 一个开放的,随机控制的试验试验,涉及18名T2DM患者.
- 参与者被随机分配 (1:1) 到一个为期8周的HIIT或MICT计划.
- 主要终点是招聘和保留率;次要终点包括calprotectin和其他生物标志物的变化.
主要成果:
- 实现了32%的招聘率,与100%的参与者保留.
- 没有报告任何不良事件,表明高安全性和可行性.
- 卡尔蛋白蛋白水平在HIIT组下降,在MICT组增加.
结论:
- 试点研究证明了有效的招聘,完整的保留和安全性,支持全面试验的可行性.
- 在HIIT中观察到的calprotectin的减少需要在更大的研究中进一步调查.
- 作为一种生活方式干预措施,HIIT显示出有前途,以控制炎症并可能降低T2DM中心血管风险.
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