相关实验视频

Updated: Jan 15, 2026

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Coculture Assays to Study Macrophage and Microglia Stimulation of Glioblastoma Invasion

Published on: October 20, 2016

在质瘤中瘤相关的巨细胞介导的化疗耐药性的进展

Xuebo Liu¹, Qi Yu¹

¹Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

Frontiers in cell and developmental biology

|October 13, 2025

概括

与瘤相关的巨细胞 (TAMs) 通过改变药物代谢和促进瘤生长来驱动质瘤中的化学抵抗. 针对TAMs,特别是M2表型,提供了有前途的治疗策略,以克服质瘤患者的治疗耐药性.

科学领域:

神经瘤学神经瘤学
癌症免疫学癌症免疫学
瘤微环境研究研究

背景情况:

瘤相关巨细胞 (TAMs) 是质瘤微环境中的关键免疫细胞.
TAMs显著促进治疗耐药性,这是质瘤管理中的一个主要障碍.

研究的目的:

审查目前关于质瘤中TAM介导化学抵抗的知识.
探索TAM异质性,极化 (M1与M2),以及它们在阻力机制中的特定作用.
总结针对TAM克服化疗抵抗的新兴治疗策略.

主要方法:

文献综述综合了目前关于质瘤中TAMs的研究.
对TAM起源,表型 (M1/M2) 和可塑性的分析.
识别TAM介导的耐药机制,包括药物代谢,因子分泌,GSC相互作用,微环境适应和ECM重塑.
针对TAMs的治疗策略概述,如重编程,代谢调节,招募阻断,耗尽和细胞增强.

主要成果:

类似M2的TAMs通过药物代谢调节,前瘤因子 (例如TNF-α,ILs,VEGF) 的分泌,与质瘤干细胞 (GSCs) 的相互作用,促进缺氧反应和细胞外矩阵 (ECM) 改造来促进化学抵抗.
存在多种治疗途径,包括重编程TAM表型,调节其新陈代谢,阻断招募途径,耗尽M2-TAM,增强细胞化.
向TAM提供了一种有希望的策略,以克服质瘤中的化学抵抗.

结论:

通过各种机制,TAMs是质瘤中化学抵抗的关键调解者.
向TAM是一种有前途的治疗途径,但像血脑屏障和补偿通路这样的挑战需要组合策略才能获得临床成功.
进一步的研究对于优化用于质瘤治疗的TAM向疗法至关重要.

关键词:

药物耐药性耐药性药物耐药性质瘤质瘤是一种重编程是重新编程.瘤微环境是一个微环境.与瘤相关的巨细胞.

更多相关视频

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...