重建设置对放射学特征强度的影响在正电子发射断层扫描图像中的强度:一项临床研究
Yinuo Liu1, Guolin Wang1, Xiaofang Yan1
1Department of Nuclear Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
肺癌PET/CT扫描中的某些放射性特征在不同的重建方法和获取设置中具有稳定性. 这种可靠性是使用这些特征作为标准化生物标志物在多中心研究和临床实践中的关键.
科学领域:
- 医疗成像医学成像
- 无线电学 (Radiomics) 是一种无线电学.
- 计算病理学计算病理学
背景情况:
- 放射性特征对图像采集和重建的变化敏感.
- 在不同的重建环境下评估放射性特征的可靠性对于其临床应用至关重要.
- 肺癌成像需要强大的定量生物标志物来进行准确的诊断和监测.
研究的目的:
- 在肺癌患者中研究正子发射断层扫描-计算机断层扫描 (PET/CT) 放射性特征的稳定性.
- 评估不同重建算法和获取设置对放射性特征稳定性的影响.
- 确定可靠的放射性特征,以便在多中心研究和临床工作流程中潜在使用.
主要方法:
- 追溯分析62名肺癌患者的18F-FDG PET/CT扫描.
- 使用OSEM,超代和基于深度学习的DPR算法重建了PET图像.
- 采集了放射性特征,并使用COV,CCC和%Diff对不同参数和获取持续时间进行了稳定性评估.
主要成果:
- 27个放射性特征在重建算法和设置中显示出高强度 (低COV,高CCC,窄%差).
- 基于强度的特征,如SUV平均值和TLG,是被发现的强大特征之一.
- 虽然平均COV在各个算法中是相似的,但CCC差异很大,算法在短期条件下显示出不同的可重现性.
结论:
- 某些放射性特征在各种重建方法,参数设置和获取持续时间中都具有稳定性.
- 确保放射学中的可复制性需要仔细考虑重建,细分和特征选择.
- 强大的放射性特征显示出作为标准化成像生物标志物的承诺,用于多中心研究和常规临床使用.
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