在慢性心力衰竭患者中,外围单细胞计数的预后意义
Atsushi Nozuhara1, Eiichiro Yamamoto1, Takashi Komorita1
1Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan.
Circulation reports
|October 13, 2025
概括
高的外围单细胞计数预测未来心力衰竭 (HF) 事件在非心力衰竭的患者与保存的喷射分数 (HFpEF),但不是在HFpEF患者. 这一发现突出显示了单细胞.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 心力衰竭 (HF) 涵盖了不同的病理生理状态,包括心力衰竭与保留喷射分数 (HFpEF) 和非HFpEF.
- 单细胞是先天免疫系统的关键组成部分,可能在HF预后中发挥作用.
研究的目的:
- 调查外围单细胞计数在预测HF相关事件中的预后价值.
- 为了区分HFpEF和非HFpEF患者组之间的单细胞计数的预后意义.
主要方法:
- 一组678名住院HF患者被根据左心室喷射率 (LVEF) 分为HFpEF和非HFpEF组.
- 根据每个LVEF类别的特定中位数,患者被分为高或低单细胞计数组.
- 采用接收器操作特征 (ROC) 分析和多变量Cox危险分析来评估单细胞计数和HF相关事件之间的关联.
主要成果:
- 高端单细胞计数 (非HFpEF的≥363/mm3,非HFpEF的≥322/mm3) 与非HFpEF组中增加的HF相关事件有关.
- 在HFpEF队列中,高和低单细胞组之间没有观察到与HF相关事件的显著差异.
- 多变量分析证实高单细胞计数作为未来HF相关事件的独立预测因子,仅在非HFpEF患者中.
结论:
- 增加的外周单细胞计数是非HFpEF患者中HF相关事件的独立和增量预测因子.
- 周围单细胞计数似乎没有显著的预后价值对于HF相关事件的HFpEF患者.
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