在使用2g瓶和使用addEASE®®连接器准备的正常盐水中评估梅罗胺添加剂中的梅罗胺稳定性
Christian M Gill1,2, Teresa Sierra3, Nicholas Kovarik1
1SSM Health Saint Louis University Hospital, MO, USA.
Hospital pharmacy
|October 13, 2025
概括
在准备好使用的分剂器件中证实了扩展输液美罗的稳定性. 这支持当前的指导方针,用于优化重症患者的美罗 (β-乳糖抗生素),简化药房的工作流程.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
- 药物的稳定性 药物的稳定性
背景情况:
- 当代指导建议延长注射β-乳糖抗生素,包括美罗,以管理高最小抑制度 (MICs) 和重症患者间的药物动力学变异性.
- 药物稳定性是延长输注梅罗的关键后勤考虑因素.
- 在准备好使用的分剂器件中证实美罗胺稳定性是有趣的.
研究的目的:
- 为了评估商业上可用的2g瓶子中的meropenem度,将其稀释在100mL普通盐水中.
- 为了评估meropenem稳定性,当使用addEASE连接器准备用于潜在的延长输注时.
主要方法:
- 使用addEASE连接器准备了五个复制袋子的美罗 (2g在100mL正常盐水中).
- 样品在0,1,2,3,4,5和6小时后被采集,并被冷保存.
- 用经过验证的高性能液体染色学与紫外线检测 (HPLC-UV) 和液体染色学-并列质谱法 (LC-MS/MS) 方法确定梅罗的度.
- 稳定性被定义为与0小时度相比,美罗胺度的恢复率>90%.
主要成果:
- 平均起始度为21.2毫克/毫升 (HPLC-UV) 和19.4毫克/毫升 (LC-MS/MS).
- 根据两种测定方法确定,在6小时的研究期间,没有一个时间点显示美罗从初始度恢复低于90%.
- 在使用这种方法制备时,在室温下6小时内,美罗的度保持稳定 (>90%的初始度).
结论:
- 用addEASE连接器制备的,在100mL普通盐水中稀释的2g瓶中的梅罗胺度在室温下保持稳定 (初始≥90%),持续6小时.
- 这种制备方法支持按照当前指导方针推的美罗的延长输注.
- 使用这种方法可以简化药房的工作流程,允许存储在自动化配药柜和床边准备,可能减少药物给药的时间.
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