手术前选择性消化清除用口服甘他素对食道切除术后术后感染的影响
Hui Jin1, Zhitao Wang1, Yuanyuan Wang2
1Department of Pharmacy, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, 317000, China.
概括
手术前选择性消化道去污染 (SDD) 用口服珍塔素显示,消化道切除术患者的手术后感染减少的趋势. 虽然这种方法在统计学上并不显著,但它降低了早期炎症标志物,因此需要进一步调查.
科学领域:
- 手术瘤学手术瘤学
- 预防传染病 预防传染病
- 胃肠道手术 胃肠道手术
背景情况:
- 癌症的胃口切除术具有严重的术后感染风险.
- 选择性消化道去污染 (SDD) 旨在通过有针对性的抗微生物使用来减少感染发生率.
- 手术前的口服珍塔米辛在SDD中对食道切除术的作用仍在调查中.
研究的目的:
- 为了评估手术前口服根他米辛基的SDD在减少癌症食道切除术后的术后感染的疗效.
- 评估SDD对炎症标志物和外科手术后恢复的影响.
主要方法:
- 对64名接受食道切除术的患者进行了回顾性队列研究.
- 主要结局:临床诊断的手术后感染.
- 费尔斯的惩罚性后勤回归用于分析数据,考虑到小样本大小和混.
主要成果:
- 在手术前服用口服 جنت米辛 (OR 0.36,P=0.12) 时,观察到较低感染风险的非显著趋势.
- 手术后感染发生在接受 gentamicin 的 14.8% 的患者中,而对照组的 32.4%.
- 接受珍塔米辛治疗的患者表现出明显较低的第1天甲水平 (P=0.009).
结论:
- 在手术前,以口服珍塔素为基础的SDD显示,手术后感染的风险数量较低,早期炎症标志物减少.
- 由于样本大小小和单中心设计,结果是探索性的.
- 更大的多中心随机试验是必要的,以确认这些初步结果.
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