基于电色DNA的生物墨水具有快速界面凝,用于生物打印应用
Yoonbin Ji1, Taehyeon Kim1, Iksoo Jang1
1Department of Chemical Engineering, University of Seoul, 163 Seoulsiripdaero, Dongdaemun-gu, Seoul 02504, Republic of Korea. jblee@uos.ac.kr.
Nanoscale horizons
|October 13, 2025
概括
我们开发了一种DNA-viologen生物墨水,可以快速形成用于组织工程的水凝. 这种电活性材料为先进的应用提供可调节性质和电响应性.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 合成生物学 合成生物学
背景情况:
- 生物制造需要先进的生物墨水,具有生物相容性,机械适用性和对生物/电信号的响应性.
- 现有的生物墨水在凝过程中往往缺乏动态反应或精确的空间控制.
研究的目的:
- 引入一种新的DNA-viologen混合生物墨水系统,用于先进的生物制造.
- 为了证明快速的,空间控制的水凝形成,具有可调节的特性和电响应.
主要方法:
- 一个DNA-viologen杂交系统的界面凝.
- 描述水凝形态,粘性弹性和可打印性.
- 在电刺激下评估可逆电色功能.
主要成果:
- 在没有外部触发的情况下,通过界面凝快速形成结构定义的水凝.
- 实现了空洞囊形态,可调节的粘弹性,以及用于软组织图案的优良打印能力.
- 在电刺激下表现出可逆的电色行为,表明动态光学反应.
结论:
- DNA-viologen生物墨水为多功能软材料提供了一个有前途的平台.
- 电活性和DNA可编程性的整合使得刺激响应材料成为可能.
- 潜在的应用包括可穿戴设备,生物传感器和先进的组织工程支架.
相关概念视频
03:31Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
01:03Fixation and Sectioning
Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...