怀孕前功能对怀孕结果的影响
Laura Cuthbertson1,2, Erandi Hewawasam3,4, Alex Kitsos5
1Department of Nephrology, St Vincent's Hospital Melbourne, Victoria, Australia.
概括
怀孕期间早期慢性病 (CKD) 会增加高血压,孕前,低出生体重和早产的风险. 怀孕前的功能评估对于管理这些风险至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 腎臟病學 (nephrology) 是一種醫學.
- 公共卫生 公共卫生
背景情况:
- 早期慢性病 (CKD) 对怀孕结果的影响尚不清楚.
- 在怀孕之前确定怀疑早期CKD的妇女对于评估母胎风险至关重要.
研究的目的:
- 为了识别疑似早期CKD预先怀孕的妇女.
- 评估早期CKD对怀孕期间母胎结局的影响.
主要方法:
- 连接全州围产,病理,脏注册和行政数据集 (2005-2023年).
- 包括18岁以上的妇女,在怀孕前5年或怀孕后30天内测量了母体血清肌素.
- 检查了与估计的膜过率 (eGFR) 和病诊断相关的母胎结局.
主要成果:
- 10例怀孕中有1例涉及女性的eGFR<90mL/min/1.73m2,蛋白尿,或诊断出病.
- 怀疑患有早期CKD的妇女患有妊娠高血压 (OR 1.21),孕前 (OR 1.26),低出生体重 (OR 1.15) 和早产 (OR 1.27) 的风险增加.
- 只有6%的eGFR<90mL/min/1.73m2的女性有量化白蛋白尿或蛋白尿测量.
结论:
- 怀孕前对功能进行评估是有必要的,因为每10个怀孕中就有1个受到早期CKD的影响.
- 虽然早期患有CKD的女性面临某些母胎并发症的风险较高,但整体绝对风险很小.
- 进一步的研究应该集中在怀孕前的功能查和管理策略上.
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