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Updated: Jan 15, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

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糖酸脱酶B (SDHB) 过度表达与酶功能障碍定义了一个明显的未分化形肉瘤亚型

Miguel Esperança-Martins1,2,3, Hugo Vasques3,4, Manuel Sokolov Ravasqueira5,6

  • 1Medical Oncology Department, Unidade Local de Saúde de Santa Maria, Lisboa, Portugal.

Cancer research communications
|October 13, 2025
PubMed
概括

不分化的多形肉瘤 (UPS) 显示高酸脱酶 (SDH) 基因表达,但酶功能受损. 这种独特的分子和代谢亚型与软组织肉瘤的预后不佳有关.

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The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
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ATP synthase or ATPase is among the most conserved proteins found in bacteria, mammals, and plants. This enzyme can catalyze a forward reaction in response to the electrochemical gradient, producing ATP from ADP and inorganic phosphate. ATP synthase can also work in a reverse direction by hydrolyzing ATP and generating an electrochemical gradient. Different forms of ATP synthases have evolved special features to meet the specific demands of the cell. Based on their specific feature, ATP...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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