在怀孕早期暴露于ravulizumab
Wolfgang Füreder1, Sonja Granser2, Andreas Repa3
1Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, A-1090, Austria. wolfgang.fuereder@meduniwien.ac.at.
在怀孕初期使用拉武利祖马布治疗阳性夜间血红蛋白尿症 (PNH) 在这种情况下不会伤害婴儿. 需要进一步的研究来证实PNH患者怀孕期间ravulizumab的安全性.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
- 生殖医学 生殖医学
背景情况:
- 孕期性夜间血红蛋白尿症 (PNH) 在历史上带来了高死亡率,主要是由于血栓栓塞.
- 像eculizumab这样的补充抑制剂已经改善了结果,但ravulizumab现在是非孕妇PNH患者的首选药物.
研究的目的:
- 报告PNH患者在怀孕早期暴露于ravulizumab的安全性.
- 评估拉武利祖马布和随后的埃奎利祖马布治疗对怀孕和婴儿后果的影响.
主要方法:
- 一个33岁的PNH患者的病例报告,她在服用ravulizumab时怀孕了.
- 患者在妊娠第11周被转换为eculizumab.
- 怀孕,胎儿发育和产后婴儿健康的详细监测.
主要成果:
- 患者在胚胎形成的关键时期接受了ravulizumab.
- 怀孕没有并发症,胎儿发育正常,男婴健康.
- 婴儿没有表现出围产期疾病的迹象,出生指标正常,在出院时身体健康.
结论:
- 在这位PNH患者的早期怀孕中暴露于ravulizumab似乎不会对孩子造成伤害.
- 需要更广泛的数据来确定ravulizumab在怀孕期间治疗PNH的安全性.
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