饮食作为代谢特征中非直接遗传影响的来源:来自基于家庭的GWAS研究的证据
Han Xiao1,2,3, Zechen Zhou1,2, Yujia Ma1,2
1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Human genetics
|October 13, 2025
概括
基于家族的全基因组关联研究 (GWAS) 揭示了对代谢特征的显著非直接遗传影响. 饮食在这些非直接的遗传机制中起着至关重要的作用,影响后代的代谢健康.
科学领域:
- 遗传学 遗传学 是一个
- 代谢表现型的代谢表现型
- 基因与环境的相互作用
背景情况:
- 使用非相关个体的全基因组关联研究 (GWAS) 可能会引入非直接的遗传偏差.
- 对代谢表型的非直接遗传影响的证据有限.
- 了解这些影响对于准确的遗传风险预测至关重要.
研究的目的:
- 使用基于家族的GWAS研究对代谢特征的非直接遗传影响.
- 确定饮食在代谢特征的非直接遗传机制中的作用.
- 为了确定特定的遗传变异和父母对后代代谢的影响.
主要方法:
- 通过使用兄弟姐妹和父母-后代三组数据,对六种代谢特征进行了基于家庭的GWAS.
- 家庭内部和基于人口的多基因评分 (PGS) 协会的比较.
- 评估了饮食对后代代谢特征的父母间接遗传影响.
- 在兄弟船内进行GWAS,以评估变体级别的非直接遗传影响.
主要成果:
- 代谢特征的家族内PGS关联平均比基于人口的估计小35.2%,表明非直接的遗传影响.
- 饮食分数显著降低了差异,确定饮食是非直接遗传影响的主要来源.
- 观察到父母的饮食间接遗传影响,例如,父母的脂肪消耗与后代血糖相关的PGS (β:0.44).
- 在GWAS内部,在排除非直接影响后,更好地确定了代谢特征的功能基因.
结论:
- 非直接的遗传影响对代谢特征有显著的贡献.
- 饮食是对新陈代谢非直接遗传影响的主要调解者.
- 在代谢研究中,基于家族的GWAS对于区分直接遗传影响与基因环境相关性至关重要.
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