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在临床实践中对QuickMIC®快速AST系统的多中心评估:与常规AST系统相比,对周转时间的影响

Anna Olsson¹, Alexandra Rafeletou¹, Amanda Åman¹

¹Gradientech AB, Dag Hammarskjölds väg 36B, Uppsala, 75237, Sweden.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

|October 13, 2025

概括

与标准方法相比,一种新的超快速抗生素敏感性测试 (AST),QuickMIC,显著减少了格拉姆阴性细菌的结果和周转时间. 这种快速的AST提供了一个有前途的解决方案,用于指导治疗严重的感染,如败血症.

科学领域:

临床微生物学临床微生物学
传染性疾病传染性疾病
诊断技术诊断技术诊断技术

背景情况:

抗生素耐药性需要快速的诊断工具来有效治疗.
血流感染和败血症需要及时的抗菌药物治疗.
目前的抗生素敏感性测试 (AST) 方法可能耗时.

研究的目的:

为了评估超快速QuickMIC系统的准确性,速度和周转时间.
为了将QuickMIC与已建立的自动化AST系统进行比较 (BD PhoenixTM,MicroScan WalkAway plus,VITEK® 2).
评估QuickMIC在多实验室临床环境中的性能.

主要方法:

同时测试阳性血液培养与格拉姆阴性细菌.
使用BD PhoenixTM,MicroScan WalkAway plus和VITEK® 2进行QuickMIC结果的比较.
分析基本协议 (EA),临床协议 (CA),偏差,结果时间 (TTR) 和周转时间 (TAT).

主要成果:

在QuickMIC® GN和常规AST系统之间,总体EA和CA超过95%.
偏差在可接受的±30%范围内.
快速MIC TTR平均为3小时4分钟,比常规系统 (9-19小时) 快得多.
对于常规系统,QuickMIC TAT的时间为10-11.5小时,而常规系统的时间为22-45小时.

结论:

快速MIC系统表现出高精度和显著降低的TTR和TAT.
快速MIC是一种有前途的快速AST技术,可在临床环境中获得可操作的结果.
这项技术有可能改善血液感染和败血症的患者管理.

关键词:

抗微生物耐药性抗微生物耐药性诊断诊断诊断诊断快速的 AST 测试可以实现.败血症这是一种败血症.

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