在高血压患者的腹腔大动脉重塑:坎帕尼亚健康网络
Costantino Mancusi1, Ilaria Fucile1, Daniela Pacella2
1Department of Advanced Biomedical Science, Federico II University, Naples, Italy.
概括
高血压可能导致腹腔大动脉 (AA) 重塑. 高血压患者的AA扩张 (≥25毫米) 与心血管风险增加和主要心血管不良事件 (MACE) 有关.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 高血压研究 高血压研究
背景情况:
- 目前的指导方针不建议进行常规的腹部大动脉 (AA) 评估.
- 高血压是腹腔大动脉动脉瘤发展的重要危险因素.
研究的目的:
- 研究高血压患者的AA维度的相关性和预测因素.
- 评估AA扩张对心血管风险的预后影响.
主要方法:
- 对3083名高血压患者 (年龄≥18岁) 的AA超声波数据的分析.
- 对AA扩张的定义是AA直径≥25mm.
- 探索与人口统计和代谢资料的相关性,多变量回归,倾向得分建模和卡普兰-梅尔生存分析.
主要成果:
- 增加的AA直径独立地与年龄,男性性别,吸烟,血压参数,LV质量指数和大动脉根尺寸有关.
- 基线使用β-阻断剂和通道阻断剂显示出显著的效果.
- 在随访期间,AA扩张 (≥25毫米) 与重大心血管不良事件 (MACE) 的风险显著增加有关.
结论:
- 腹腔大动脉重塑受到心血管风险因素和高血压相关的目标器官损伤的显著影响.
- 腹腔大动脉扩张是治疗高血压患者心血管风险增加的一个因素.
相关概念视频
Abdominal Aorta
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Hypertension II: Pathophysiology
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Aneurysm III: Interprofessional Care
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

