在传播脑炎中,N-甲基-D-酸盐受体自身免疫的低频率
Jakob Morén1,2, Barbro Persson3, Anna Sörman3
1Infection Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
PloS one
|October 13, 2025
概括
对N-甲基-D-酸盐受体 (抗NMDAR) 的自身抗体在传播脑炎后很少发生. 需要进一步的研究来了解它们在某些患者认知问题中的作用.
科学领域:
- 神经免疫学 神经免疫学
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 传染性脑炎 (TBE) 是一种中枢神经系统的病毒感染,其机制和潜在的长期影响尚不清楚.
- 自身免疫性脑炎,其特征是对N-甲基-D-酸盐受体 (抗NMDAR) 的自身抗体,可以由各种事件触发,并可能使其他脑炎的恢复复杂化.
- 虽然TBE与抗NMDAR脑炎有关,但这种自身免疫的发生频率尚不清楚.
研究的目的:
- 为了确定TBE后内抗NMDAR抗体发育的频率.
- 调查抗NMDAR抗体与TBE患者的认知投诉之间的潜在关联.
主要方法:
- 对被诊断患有TBE的成年患者进行了回顾性和前性分析.
- 使用两个商业套件检测脑脊液 (CSF) 中的抗NMDARIgG抗体.
- 分析了来自53名患者的71个脑脊髓液样本,收集的中位数是症状出现后的91天.
主要成果:
- 在一个TBE患者的CSF样本中检测到抗NMDAR抗体.
- 这代表了研究TBE患者队列中的1.9% (95%CI:0.05-10.1%) 的发病率.
- 阳性样本使用Euroimmun AG套件进行鉴定.
结论:
- 在TBE之后,内抗NMDAR自身抗体的发展很少发生.
- 这些抗体对患者子组认知结果的临床意义需要进一步调查.
- 对于经过康复后临床衰退的TBE患者,可能需要考虑在CSF中进行抗NMDAR抗体测试.
相关概念视频
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Encephalitis l: Introduction
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...


