疫苗接种范围的社会不平等及其对流行病传播的影响
Adriana Manna1, Márton Karsai1,2, Nicola Perra3,4
1Department of Network and Data Science, Central European University, Vienna, Austria.
PLoS computational biology
|October 13, 2025
概括
疫苗接种的社会经济不平等加重了疾病负担,尤其是对弱势群体来说. 将社会经济地位纳入流行病模型对于公平的公共卫生战略和有效的疫苗接种活动至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生建模公共卫生建模
- 健康 公平 卫生 公平
背景情况:
- 疫苗是关键的公共卫生工具,但社会经济群体之间不平等的接种限制了他们的有效性.
- 当前的流行病模型往往忽视了疫苗接种范围的社会经济差异,阻碍了准确的预测和干预评估.
研究的目的:
- 调查疫苗接种中社会经济不平等对疾病负担,特别是发病率的影响.
- 评估包含社会经济地位 (SES) 的模型与不包含社会经济地位的模型的预测准确性.
主要方法:
- 开发了一个模型框架,使用了包括SES变量以及年龄在内的通用接触矩阵.
- 在两个疫苗接种时间场景下模拟的流行病动态:与流行病浪潮并发和之前.
- 用合成和实证的通用接触矩阵进行分析.
主要成果:
- 疫苗接种范围的社会经济不平等导致对疾病结果的非线性影响,并增加弱势群体的疾病负担.
- 忽视SES异质性的模型产生了偏见或不完整的攻击率预测.
- 疫苗接种范围的不平等与非药物干预 (NPI) 相互作用,扩大了各子组之间的差异.
结论:
- 将SES维度集成到流行病建模中,对于理解和解决健康不平等问题至关重要.
- 准确的建模需要考虑社会经济异质性,以告知有效和公平的公共卫生干预和疫苗接种策略.
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